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EVOLVE Short DAPT – 3 Month Dual Antiplatelet Therapy (DAPT) with SYNERGYTM Stent System

Study Type/Phase: Interventional
Status: Not Recruiting

This is a prospective, multicenter study designed to assess the safety of 3-month dual antiplatelet therapy (DAPT) in subjects at high risk for bleeding undergoing percutaneous coronary intervention (PCI) with the SYNERGY™ Everolimus-Eluting Platinum Chromium Coronary Stent System (Synergy Stent System).

Coronary artery disease is a narrowing of one or more blood vessels (coronary arteries) that supply blood and oxygen to the heart. Coronary stenting is a commonly used procedure to treat coronary artery disease. A stent is a small mesh tube that is placed in the artery through a catheter or PCI to treat weak or narrowed arteries. The FDA approved SYNERGY stent is a drug-eluding stent that has been shown to promote healing and prevent re-narrowing of the coronary arteries. The purpose of this study will be to research the safety of aspirin plus 3 months of a second blood thinner (antiplatelet) medication [clopidogrel (Plavix), or prasugrel (Effient), or ticagrelor (Brilinta)] in people who have a SYNERGY stent.

Speak with your doctor to determine whether you meet the following criteria for participation in this study.

Inclusion Criteria Exclusion Criteria
  • Considered at high risk for bleeding
  • ≥ 75 years of age
  • Need for continued anticoagulation therapy
  • History of major bleeding
  • History of stroke
  • Renal insufficiency or dialysis dependent
  • Must have SYNERGY stent placement within the preceding 3 calendar days of study enrollment
  • Must be able to take the required antiplatelet therapy
  • Willing to comply with study requirements to stop taking P@Y12 inhibitor at the 3-month milestone, if eligible.


Principal Investigator

Chad Rammohan, MD


Boston Scientific

NCT Number



Kara Turner, Clinical Research Coordinator
Taft Center for Clinical Research


For more information about this clinical trial, including trial status, eligibility and full trial listing, visit


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